The A487 between Aberarth and Llanon is currently closed due to a collision.
Dyfed-Powys Police is urging motorists to find alternative routes.
Posting to social media at around 2.30pm on Monday, Dyfed-Powys Police said: "A487 - Aberarth to Llanon.
"The road is currently closed due to a collision.
"Please avoid the area and find alternative routes for your journey."
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