The A44 Llangurig to Ponterwyd road is closed.
Dyfed-Powys Police say the road is closed following a collision. They are appealing to people avoid the area and find an alternative route.
A post on Dyfed-Powys Police' social media page says: "The road is currently closed due to a collision.
"Please avoid the area and find alternative routes for your journey.
We'll bring you more news as we get it.