The Seagulls enter uncharted territory and will be buoyed by a confident display, based initially on a dour but effective defence - and then an offensive onslaught which Usk were unable to repel.
The visitors contained a heavy front eight and for the first quarter took the game to Aberaeron. Indeed, the hosts found it difficult to escape from their own half for this period, but the visitors’ only reward came from a penalty by Josh Guy.
The restart signalled a major turnaround in fortunes and for the first time the home eight started to dominate, and within minutes the tide had turned with a series of rolling mauls threatening the away line.
The pressure finally told when, following a concerted effort by the front row trio of Danton, Evans and Wozencraft , second row Gethin Hughes was able to extend his long arms over the whitewash for the try.
The versatile Rhodri Thomas, who was playing in his third positional spot this year, calmly stroked over the conversion.
It got even better for Aberaeron just a few minutes later as burly scrum half Gareth James burrowed his way over for the second score - for what had initially seemed an unlikely 12-3 lead at half time.
The second half, however, was a different story as the home team dominated proceedings and never really looked at being at risk of releasing the noose.
With the Llewelyn brothers threatening on the counter attack, a quick release provided Tom Slinger with an opening and from half way the centre brushed aside would-be tacklers to cross near the posts, allowing Thomas an easy conversion.
Not to be outdone, Usk took full advantage of a breakdown in play on half way and gave themselves a glimmer of hope with a surge which resulted in a well worked try by Andre Peggington, which was then successfully converted by Guy.
This however became a false dawn as a calm Thomas stroked over a penalty, and this was followed by the best sequence in play when the back row of Tudur Jenkins and Aaron Lewis combined to allow fellow flanker and man of the match Dan Lewis to scamper over the line, allowing Thomas to conjure up another conversion.
Usk did take the late honours with a try at the final whistle, but it was a case of too little too late for any upset and the jubilation at the final whistle summed up a rewarding but hard earned afternoon.
Aberaeron now travel to face Oakdale in the last light eight on Saturday, 2 March, and whisper it quietly, they are just two wins away from a final at the Principality Stadium.